請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62075
標題: Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway
作者: Shih, P.H.
顏國欽
Yen, G.C.
關鍵字: oxidative stress
antioxidant enzyme
aging
signal transduction
mitogen-activated protein kinase (MAPK)
nuclear factor-erythroid 2
p45-related factor 2 (Nrf2)
superoxide-dismutase
glutathione
gene
age
catalase
enzymes
protein
mechanisms
induction
stress
期刊/報告no:: Biogerontology, Volume 8, Issue 2, Page(s) 71-80.
摘要: Antioxidant enzymes (AOEs) play an important role in the protection of cells against reactive oxygen species and facilitate the prevention of oxidative stress-induced aging. In the present study, the antioxidant indices, including the content of peroxidation product and the expression of AOEs in rat livers of varying ages (2, 12 and 18-24 months old) were evaluated. Erythrocytes haemolysis induced by free radicals showed significant age-dependent increases (P < 0.05). The content of oxidation products in livers showed that increasing age was associated with serious oxidative injury. The activities of AOEs decreased with increasing age. Expression of the antioxidant and age-related gene, klotho, decreased with increasing age. Western blot assay showed that aged rats experience higher levels of oxidative stress. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) exhibited an age-dependent decrease. Additionally, the mitogen-activated protein kinase cascade (MAPK) played a regulatory role in signaling transduction. Overall, we suggest that age-related declines of the antioxidant defense are closely involved with the expression of Nrf2 and are regulated by the MAPK family.
URI: http://hdl.handle.net/11455/62075
ISSN: 1389-5729
文章連結: http://dx.doi.org/10.1007/s10522-006-9033-y
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