請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62075
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dc.contributor.authorShih, P.H.en_US
dc.contributor.author顏國欽zh_TW
dc.contributor.authorYen, G.C.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-09T06:26:22Z-
dc.date.available2014-06-09T06:26:22Z-
dc.identifier.issn1389-5729zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62075-
dc.description.abstractAntioxidant enzymes (AOEs) play an important role in the protection of cells against reactive oxygen species and facilitate the prevention of oxidative stress-induced aging. In the present study, the antioxidant indices, including the content of peroxidation product and the expression of AOEs in rat livers of varying ages (2, 12 and 18-24 months old) were evaluated. Erythrocytes haemolysis induced by free radicals showed significant age-dependent increases (P < 0.05). The content of oxidation products in livers showed that increasing age was associated with serious oxidative injury. The activities of AOEs decreased with increasing age. Expression of the antioxidant and age-related gene, klotho, decreased with increasing age. Western blot assay showed that aged rats experience higher levels of oxidative stress. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) exhibited an age-dependent decrease. Additionally, the mitogen-activated protein kinase cascade (MAPK) played a regulatory role in signaling transduction. Overall, we suggest that age-related declines of the antioxidant defense are closely involved with the expression of Nrf2 and are regulated by the MAPK family.en_US
dc.language.isoen_USzh_TW
dc.relationBiogerontologyen_US
dc.relation.ispartofseriesBiogerontology, Volume 8, Issue 2, Page(s) 71-80.en_US
dc.relation.urihttp://dx.doi.org/10.1007/s10522-006-9033-yen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant enzymeen_US
dc.subjectagingen_US
dc.subjectsignal transductionen_US
dc.subjectmitogen-activated protein kinase (MAPK)en_US
dc.subjectnuclear factor-erythroid 2en_US
dc.subjectp45-related factor 2 (Nrf2)en_US
dc.subjectsuperoxide-dismutaseen_US
dc.subjectglutathioneen_US
dc.subjectgeneen_US
dc.subjectageen_US
dc.subjectcatalaseen_US
dc.subjectenzymesen_US
dc.subjectproteinen_US
dc.subjectmechanismsen_US
dc.subjectinductionen_US
dc.subjectstressen_US
dc.titleDifferential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathwayen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1007/s10522-006-9033-yzh_TW
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