請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62077
標題: Pro-oxidative properties of flavonoids in human lymphocytes
作者: Yen, G.C.
顏國欽
Duh, P.D.
Tsai, H.L.
Huang, S.L.
關鍵字: flavonoid
pro-oxidant
DNA damage
lymphocyte
oxygen-free-radicals
lipid-peroxidation
dna-damage
hydrogen-peroxide
glutathione-reductase
prooxidant actions
strand breaks
antioxidant
acid
liver
期刊/報告no:: Bioscience Biotechnology and Biochemistry, Volume 67, Issue 6, Page(s) 1215-1222.
摘要: The pro-oxidative properties of the four flavonoids, quercetin, morin, naringenin and hesperetin, in human lymphocyte system were investigated. Naringenin and hesperetin accelerated the oxidation of deoxyribose induced by Fe(3+)/H(2)O(2) in a concentration range of 0-200 mum, but quercetin and morin decreased it when the concentration was greater than 100 mum. The generation of hydrogen peroxide and the superoxide anion and the production of TBARS in lymphocytes were increased with increasing concentration of a flavonoid. Cell membrane protein thiols of the lymphocytes decreased when treated with the four flavonoids. Quercetin and hesperetin had no significant effect (p>0.05) on the activity of glutathione reductase, but morin and naringenin could inhibit the activity of the enzyme at a concentration of 200 mum, when compared to the control group. The glutathione S-transferase activity was slightly decreased by treatment with each of the four flavonoids only at a concentration of 200 mum. Therefore, the DNA damage in lymphocytes induced by the flavonoids in the model system might have been due to their stimulation of oxidative stress in the lymphocytes, which resulted in the decrease of cell membrane protein thiols, increase of lipid peroxidation in cell membrane and in the influence of the antioxidative enzyme activities.
URI: http://hdl.handle.net/11455/62077
ISSN: 0916-8451
顯示於類別:食品暨應用生物科技學系

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