請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62078
標題: Scavenging effect of various tea extracts on superoxide derived from the metabolism of mutagens
作者: Yen, G.C.
顏國欽
Chen, H.Y.
關鍵字: tea extract
superoxide
scavenging effect
mutagen
oxygen-free-radicals
inhibition
induction
oxidation
cancer
期刊/報告no:: Bioscience Biotechnology and Biochemistry, Volume 62, Issue 9, Page(s) 1768-1770.
摘要: We determine the superoxide formed in the self-degradation of mutagens activated by cytochrome enzymes and evaluated the scavenging effect of various tea extracts. Benzo[a]pyrene (B[a]P) and 2-amino-6-methyldipyrido(1,2-a:3',2'-d)imidazole (Glu-P-1) each produced a large amount of superoxide after activation by cytochrome enzymes. However, 2-amino-3-methyl-imidazo(4,5-f)quinoline (IQ), 3-amino-1,4-dimethyl-5H-pyridol(4,3-b)indole (Trp-P-1) and alfatoxin B-1 (APB(1)) failed to generate a significant amount of superoxide. The addition of a tea extract to the reaction system marked inhibited the derivation of superoxide from Glu-P-1. However, the tea extracts showed weaker inhibition of the B[a]P-mediated formation of superoxide. Among the four teas tested, the oolong tea extract tended to exhibit the strongest inhibitory effect. Our results suggest that the chemopreventive efficacy of a tea extract is partly associated with its antioxidative activity.
URI: http://hdl.handle.net/11455/62078
ISSN: 0916-8451
文章連結: http://dx.doi.org/10.1271/bbb.62.1768
顯示於類別:食品暨應用生物科技學系

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