請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62079
標題: Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats
作者: Hsu, C.L.
顏國欽
Yen, G.C.
關鍵字: gallic acid
high-fat diet
anti-obesity
lipid-peroxidation
antioxidant activity
plasma adiponectin
antiobesity action
induced obesity
phenolic-acids
3t3-l1 cells
mice
expression
disease
期刊/報告no:: British Journal of Nutrition, Volume 98, Issue 4, Page(s) 727-735.
摘要: Gallic acid (GA) is a naturally abundant plant phenolic compound in the human diet and is known to reduce the risk of disease. In this study, the anti-obesity effect of GA in an animal model of diet-induced obesity was investigated. Obesity was induced in male Wistar rats by feeding them a high-fat diet (HFD). GA was given as a supplement at the levels of 50 and 100 mg/kg rat for a period of 10 weeks. The results showed that the body weight, organ weight of the liver and adipose tissue weights of peritoneal and epididymal tissues in the HFD + GA groups were significantly decreased as compared with the HFD group. Serum TAG, phospholipid, total cholesterol, LDL-cholesterol, insulin and leptin levels in the HFD + GA groups were significantly decreased as compared with the HFD group. Histological study showed that the lipid droplets of rats with HFD + GA diets were significantly smaller than those with HFD diets. Hepatic TAG and cholesterol levels in HFD + GA groups were significantly decreased as compared with the HFD group. Moreover, the consumption of GA reduced oxidative stress and GSSG content and enhanced the levels of glutathione, GSH peroxidase, GSH reductase and GSH S-transferase in the hepatic tissue of rats with HFD-induced obesity. These results demonstrate that intake of GA can be beneficial for the suppression of HFD-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats.
URI: http://hdl.handle.net/11455/62079
ISSN: 0007-1145
文章連結: http://dx.doi.org/10.1017/s000711450774686x
顯示於類別:食品暨應用生物科技學系

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