請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62086
標題: Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells
作者: Hsu, C.L.
顏國欽
Lin, Y.J.
Ho, C.T.
Yen, G.C.
關鍵字: conjugated linoleic-acid
antioxidant activity
adipose conversion
metabolic syndrome
phenolic-acids
pre-adipocytes
apoptosis
adiponectin
obesity
suppression
期刊/報告no:: Food & Function, Volume 3, Issue 1, Page(s) 49-57.
摘要: The aim of this work was to study the effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. The results showed that garcinol and pterostilbene decreased the cell population growth and caused cell cycle arrest at the G2/M phase in 3T3-L1 preadipocytes. During adipocyte differentiation, both garcinol and pterostilbene had inhibitory effects on fat droplet formation and triacylglycerol accumulation. The data indicated that garcinol and pterostilbene could inhibit the glycerol-3-phosphate dehydrogenase (GPDH) activity by 97.8 and 61.5%, respectively, as compared to the control. Both garcinol and pterostilbene significantly attenuated the protein expressions of PPAR gamma and C/EBP alpha during 3T3-L1 adipocyte differentiation. Moreover, garcinol and pterostilbene caused an inhibition of lipid accumulation in the 3T3-L1 adipocyte differentiation phase. Garcinol and pterostilbene also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin, resistin, and fatty acid synthase (FAS) in 3T3-L1 adipocyte differentiation. In 3T3-L1 adipocytes, garcinol significantly down-regulated the protein expressions of PPAR gamma and FAS as well as up-regulated the protein expressions of adipose triglyceride lipase (ATGL) and adiponectin. Garcinol also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin and FAS. These results suggest that garcinol and pterostilbene have anti-adipogenic effects on preadipocytes and adipocytes.
URI: http://hdl.handle.net/11455/62086
ISSN: 2042-6496
文章連結: http://dx.doi.org/10.1039/c1fo10209e
顯示於類別:食品暨應用生物科技學系

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