請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62092
標題: Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation
作者: Shyu, M.H.
顏國欽
Kao, T.C.
Yen, G.C.
關鍵字: Hsian-tsao
Liver fibrogenesis
Oleanolic acid
Ursolic acid
Hepatic
stellate cell
oleanolic acid glycosides
ursolic acid
carbon-tetrachloride
matrix
metalloproteinases
damage
proliferation
constituents
mechanisms
expression
lipocytes
期刊/報告no:: Food and Chemical Toxicology, Volume 46, Issue 12, Page(s) 3707-3713.
摘要: In this study, the protective effect of extract of Hsian-tsao (Mesona procumbens) (EHT) against liver fibrogenesis in carbon tetrachloride (CCl(4))-injured rats was evaluated. The inhibitory effect of oleanolic acid (OA) and Ursolic acid (UA), which are the active compounds in EHT, on the activation of hepatic stellate cells (HSC) was also determined. The results showed that EHT at a dosage of 1.2 g/kg of b.w. significantly reduced the liver injury induced by CCl(4) in rats. It also decreased the activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the deposition of collagen in the liver. Oral administration of EHT reduced the levels of alpha-smooth muscle actin (alpha-SMA) and the activity of metalloproteinases (MMPs) in rats injured by treatment with CCl(4)- In addition, we performed experiments with the rat hepatic stellate cell line HSC-T6 in which we induced the expression of MMP-2 and alpha-SMA with phorbol-12-myristate-13-acetate (PMA). Treating these cells with OA (20 mu M) or UA (10 mu M) caused a decrease in the levels of both proteins. Taken together, our data indicate that EHT can efficiently inhibit CCl(4)-induced liver fibrosis in rats. EHT may therefore be a useful functional food for preventing liver fibrosis. (C) 2008 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/62092
ISSN: 0278-6915
文章連結: http://dx.doi.org/10.1016/j.fct.2008.09.051
顯示於類別:食品暨應用生物科技學系

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