請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62094
標題: Protective effect of extracts of Mesona procumbens Hemsl. on DNA damage in human lymphocytes exposed to hydrogen peroxide and UV irradiation
作者: Yen, G.C.
顏國欽
Hung, Y.L.
Hsieh, C.L.
關鍵字: Mesona procumbens
lymphocytes
H2O2
UV
DNA damage
comet assay
strand breaks
human-cells
oxidized pyrimidines
phenolic-compounds
comet assay
antioxidant
repair
flavonoids
prooxidant
absorption
期刊/報告no:: Food and Chemical Toxicology, Volume 38, Issue 9, Page(s) 747-754.
摘要: In the present study, the protective effect of mater extracts from Hsian-tsao (WEHT) on DNA damage in human lymphocytes induced by W-C and/or H2O2 was evaluated using single-cell electrophoresis (comet assay). No toxicity was found in WEHT towards human lymphocytes. WEHT did not cause DNA damage at loser concentrations of 0.05 and 0.1 mg/ml, while it did cause slight DNA damage at a concentration of 0.5-2.5 mg/ml when compared with the control group. When WEHT was mixed with H2O2 for reaction, it exhibited a slight inhibitory effect on DNA damage induced by H2O2 Moreover, when WEHT and lymphocytes were irradiated by UV-C and then incubated for 35 min, the DNA damage decreased with an increase of the concentration of WEHT. Thus, WEHT could reduce UV-C-induced DNA damage, and WEHT had a more protective effect on UV-C than on H2O2-induced DNA damage. The protective effect of WEHT on DNA damage might be due to the fact that it contains polyphenol compounds and/or other active components. (C) 2000 Elsevier Science Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/62094
ISSN: 0278-6915
文章連結: http://dx.doi.org/10.1016/s0278-6915(00)00069-7
顯示於類別:食品暨應用生物科技學系

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