請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62113
標題: Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis
作者: Shih, P.H.
顏國欽
Yeh, C.T.
Yen, G.C.
關鍵字: anthocyanins
reactive oxygen species
chemoprevention
antioxidant
response element (ARE)
apoptosis
gene-expression
pc12 cells
cancer
glutathione
rich
identification
hepatocytes
capacity
sequence
cyanidin
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 55, Issue 23, Page(s) 9427-9435.
摘要: Reactive oxygen species (ROS)-induced cell damage is inevitable and severe and is involved in numerous diseases, including cancer. Reducing oxidative stress is one of the strategies of chemoprevention. Anthocyanins are naturally occurring flavonoids that show multiple benefits. We first pointed out the effects of anthocyanins in the contributions to activation of phase 11 antioxiclant and detoxifying enzymes, chemopreventive potency, and involved transcriptional regulation. Our results obtained in rat liver Clone 9 cells showed that treatment of anthocyanins leads to positive effects on elevating the antioxidant capacity, including activated expression of glutathione-related enzymes (glutathione reductase, glutathione peroxidase, and glutathione S-transferase) and recruited GSH content. In addition, the activity of NAD(P)H: quinone oxidoreductase (NQO1) was also promoted under the treatment of anthocyanin. This influential functions as the defense system against programmed cell death induced by H2O2. The capacity for induction of luciferase expression by anthocyanins in cells transfected with rat nqo1-promoter constructed plasmid was further investigated; we found that the molecular mechanism is related to the activation of antioxidant response element (ARE) upstream of genes that are involved in antioxidation and detoxification. Our data suggest that natural anthocyanins are recommended as chemopreventive phytochemicals and could stimulate the antioxiclant system to resist oxidant-induced injury. And, more important, the promoting effect of anthocyanins on ARE-regulated phase 11 enzyme expression seems to be a critical point in modulating the defense system against oxidative stress.
URI: http://hdl.handle.net/11455/62113
ISSN: 0021-8561
文章連結: http://dx.doi.org/10.1021/jf071933i
顯示於類別:食品暨應用生物科技學系

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