請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62116
標題: Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus
作者: Fang, S.C.
顏國欽
Hsu, C.L.
Yen, G.C.
關鍵字: Artocarpus heterophyllus
anti-inflammation
inducible nitric oxide
synthase
cyclooxygenase 2
oxide synthase expression
nitric-oxide
cyclooxygenase-2 expression
oxidative stress
kappa-b
flavonoids
superoxide
elasticus
cells
prenylflavonoids
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 56, Issue 12, Page(s) 4463-4468.
摘要: Artocarpus heterophyllus Lam is a large evergreen tree cultivated throughout Southeast Asia for its fruits. Its leaves and roots have been used for medicinal purposes. The aim of this work was to study the in vitro anti-inflammatory effects of phenolic compounds isolated from the ethyl acetate extracts of the fruits of Artocarpus heterophyllus. Three phenolic compounds were characterized as artocarpesin [5,7,2', 4'-tetrahydroxy-6-(3-methylbut-3-enyl) flavone] (1), norartocarpetin (5,7,2',4'-tetrahydroxyflavone) (2), and oxyresveratrol [trans-2,4,3',5'-tetrahydroxystilbene] (3) by spectroscopic methods and through comparison with data reported in the literatures. The anti-inflammatory effects of the isolated compounds (1-3) were evaluated by determining their inhibitory effects on the production of proinflammatory mediators in lipopolysaccharide (LPS)-activated RAW 264.7 murine macrophage cells. These three compounds exhibited potent anti-inflammatory activity. The results indicated that artocarpesin (1) suppressed the LPS-induced production of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) through the down-regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) protein expressions. Thus, artocarpesin (1) may provide a potential therapeutic approach for inflammation-associated disorders.
URI: http://hdl.handle.net/11455/62116
ISSN: 0021-8561
文章連結: http://dx.doi.org/10.1021/jf800444g
顯示於類別:食品暨應用生物科技學系

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