請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62148
標題: Neuroprotective Effects of Glycyrrhizic Acid and 18 beta-Glycyrrhetinic Acid in PC12 Cells via Modulation of the PI3K/Akt Pathway
作者: Kao, T.C.
顏國欽
Shyu, M.H.
Yen, G.C.
關鍵字: Glycyrrhizic acid
18 beta-glycyrrhetinic acid
mitochondria
PI3K/Akt
pathway
neuroprotection
nerve growth-factor
factor-kappa-b
oxidative stress
mitochondrial
dysfunction
ascorbic-acid
apoptosis
expression
death
antioxidant
protects
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 57, Issue 2, Page(s) 754-761.
摘要: Glycyrrhizic acid (GA) and 18 beta-glycyrrhetinic acid (18 beta GA) are the bioactive compounds of licorice. The neuroprotective effects of GA and 18 beta GA against serum/glucose deprivation and 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in PC12 cells were investigated. The intracellular reactive oxygen species (ROS) content, the activity of the antioxidant enzymes of glutathione peroxidase (GPx) and catalase, the mitochondrial membrane potential (MMP), and the mitochondrial Bax/Bcl-2 ratio were determined. PI3K/Akt pathway signaling was also evaluated to study the possible protective mechanism. The results showed that GA treatment decreased the ROS content by elevating the activities of GPx and catalase, leading to a decreased MMP. GA and 18 beta GA also lowered the mitochondrial Bax/Bcl-2 ratio and activated PI3K/Akt signal. The results suggest that GA may protect PC12 cells from ischemic injury via modulation of the intracellular antioxidant system and mitochondria-induced apoptosis. Moreover, GA and 18 beta GA may modulate the ratio of the mitochondrial Bcl-2 family and influence PI3K/Akt signaling. These results demonstrate the neuroprotective ability of GA and 18 beta GA and suggest that the cytotoxicity of 6-OHDA may influence the mitochondrial Bax/Bcl-2 ratio without altering the expression of Bax. This study also suggests a possible compound for treating neural disease and general neuronal health.
URI: http://hdl.handle.net/11455/62148
ISSN: 0021-8561
文章連結: http://dx.doi.org/10.1021/jf802864k
顯示於類別:食品暨應用生物科技學系

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