請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62169
標題: Inducing gene expression of cardiac antioxidant enzymes by dietary phenolic acids in rats
作者: Yeh, C.T.
顏國欽
Ching, L.C.
Yen, G.C.
關鍵字: Cardioprotection
Heart
Antioxidant enzymes
Heme oxygenase-1
Antioxidant capacity
drug-metabolizing-enzymes
heme oxygenase-1 gene
phase-ii enzymes
transcription factor
gallic acid
nrf2
induction
pathway
injury
heart
期刊/報告no:: Journal of Nutritional Biochemistry, Volume 20, Issue 3, Page(s) 163-171.
摘要: An increase in oxidative stress is suggested to be intimately involved in the pathogenesis of heart failure. Phenolic acids are widespread in plant foods; they contain important biological and pharmacological properties. This study evaluated the role of phenolic acids on the expression of antioxidant enzymes in the heart of male Sprugue-Dawley rats. Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg (1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT) as compared with control rats (P<.05). The changes in cardiac CuZnSOD, GPx and CAT mRNA levels induced by phenolic acids were similar to those noted in the enzyme activity levels. A significant (P<.05) increase in the GSII/GSSG ratio was observed in the heart of phenolic acid-treated rats. The heart homogenates obtained from rats that were administered phenolic acids displayed significant (P<.05) increases in capacity for oxygen radical absorbance compared with control rats. Immunoblot analysis revealed the increased cardiac total level of Nrf2 in phenolic acid-treated rats. Interestingly, phenolic acid-mediated antioxidant enzyme expression was accompanied by tip-regulation of heme oxygenase-1. This study demonstrates that antioxidant enzymes in rat cardiac tissue can be significantly induced by phenolic acids following oral administration. (C) 2009 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/62169
ISSN: 0955-2863
文章連結: http://dx.doi.org/10.1016/j.jnutbio.2008.01.005
顯示於類別:食品暨應用生物科技學系

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