Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62181
標題: Cytoprotective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells
作者: Huang, S.M.
顏國欽
Chuang, H.C.
Wu, C.H.
Yen, G.C.
關鍵字: cytoprotection
glycation
methylglyoxal
Neuro-2A cells
phenolic acids
advanced glycation endproducts
imidazolium cross-links
alzheimers-disease
maillard reaction
oxidative stress
diabetic
complications
glyoxalase system
protein-kinases
in-vitro
accumulation
期刊/報告no:: Molecular Nutrition & Food Research, Volume 52, Issue 8, Page(s) 940-949.
摘要: In the process of glycation, methylglyoxal is a reactive dicarbonyl compound physiologically generated as an intermediate of glycolysis, and is found in high levels in blood or tissue of diabetic models. Biological glycation has been commonly implicated in the development of diabetic microvascular complications Of neuropathy. Increasing evidence suggests that neuronal cell cycle regulatory failure followed by apoptosis is an important mechanism in the development of diabetic neuropathy complication. Naturally occurring antioxidants, especially phenolic acids have been recommended as the major bioactive compounds to prevent chronic diseases and promote health benefits. The objective of this Study was to investigate the inhibitory abilities of phenolic acids (chlorogenic acid, syringic acid and vanillic acid) on methylglyoxal-induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis in the progression of diabetic neuropathy. The data indicated that methylglyoxal induced mouse Neuro-2A neuroblastoma (Neuro-2A) cell apoptosis via alternation of mitochondria membrane potential and Bax/Bcl-2 ratio. activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase. Furthermore, the results demonstrated that activation of mitogen-activated protein kinase signal pathways (JNK and p38) participated in the methylglyoxal-induced Neuro-2A cell apoptosis process. Treatment of Neuro-2A cells with phenolic acids markedly suppressess cell apoptosis induced by methylglyoxal., suggesting that phenolic acids possess cytoprotective ability in the prevention of diabetic neuropathy complication
URI: http://hdl.handle.net/11455/62181
ISSN: 1613-4125
文章連結: http://dx.doi.org/10.1002/mnfr.200700360
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