Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62210
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dc.contributor.authorWeng, C.J.en_US
dc.contributor.author顏國欽zh_TW
dc.contributor.authorChau, C.F.en_US
dc.contributor.authorYen, G.C.en_US
dc.contributor.authorLiao, J.W.en_US
dc.contributor.authorChen, D.H.en_US
dc.contributor.authorChen, K.D.en_US
dc.contributor.author周志輝zh_TW
dc.contributor.author廖俊旺zh_TW
dc.date2009zh_TW
dc.date.accessioned2014-06-09T06:26:36Z-
dc.date.available2014-06-09T06:26:36Z-
dc.identifier.issn0021-8561zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62210-
dc.description.abstractMetastasis is considered to be the major cause of death in patients with cancers, and hepatocellular carcinoma (HCC) is a highly metastatic cancer. Ganoderma lucidum, a well-known mushroom with various biological effects, is a functional food known to contain lucidenic acid, The objectives of this study were to investigate the anti-invasion effect of a lucidenic acid-rich G. lucidum extract (GLE) on human hepatoma HepG2 cells as well as the antiproliferative and antimetastatic effects of GLE in human hepatoma cells implanted into ICR-nu/nu mice. Phorbol-12-myristate-13-acetate (PMA)-induced invasion and matrix metalloproteinase (MMP)-9 expression levels of HepG2 cells were reduced by GLE treatment in a dose-dependent manner. The inhibitory effects of GLE on MMP-9 expression proceeded by inhibiting the phosphorylation of extracellular signal-regulated kinase (ERK1/2) and protein kinase B in the cytosol as well as reducing activator protein-1 and nuclear factor-kappa B levels in the nucleus of HepG2 cells. In a human tumor xenograft model, a dose-response inhibition was observed in the average size, volume, and weight of tumors upon oral administration of GLE. The number of metastatic tumor-bearing mice, the number of affected organs, and the number of tumor foci as well as the MMP-2 and -9 activities in serum of mice were also significantly suppressed by oral administration of GLE. These results suggest that the lucidenic acid-rich GLE could serve as a chemopreventive agent for the tumorigenesis and metastasis of highly invasive hepatoma cells.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Agricultural and Food Chemistryen_US
dc.relation.ispartofseriesJournal of Agricultural and Food Chemistry, Volume 57, Issue 11, Page(s) 5049-5057.en_US
dc.relation.urihttp://dx.doi.org/10.1021/jf900828ken_US
dc.subjectGanoderma lucidumen_US
dc.subjectinvasionen_US
dc.subjectlucidenic aciden_US
dc.subjectmetastasisen_US
dc.subjectMMP-9 activityen_US
dc.subjectsignal-transduction pathwayen_US
dc.subjectnf-kappa-ben_US
dc.subjecthepatocellular-carcinomaen_US
dc.subjectmatrix metalloproteinasesen_US
dc.subjectinvasionen_US
dc.subjecttumoren_US
dc.subjectoverexpressionen_US
dc.subjectcanceren_US
dc.subjectmatrix-metalloproteinase-9en_US
dc.subjectproliferationen_US
dc.titleInhibitory Effects of Ganoderma lucidum on Tumorigenesis and Metastasis of Human Hepatoma Cells in Cells and Animal Modelsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/jf900828kzh_TW
Appears in Collections:食品暨應用生物科技學系
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