Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/66625
標題: Genetic and pathogenic characterization of H6N1 avian influenza viruses isolated in Taiwan between 1972 and 2005
作者: Lee, M.S.
張伯俊
Chang, P.C.
Shien, J.H.
Cheng, M.C.
Chen, C.L.
Shieh, H.K.
關鍵字: avian influenza virus
H6Nl
Taiwan
southern china
interspecies transmission
antigenic structure
escape
mutants
a viruses
hemagglutinin
subtype
humans
identification
evolution
期刊/報告no:: Avian Diseases, Volume 50, Issue 4, Page(s) 561-571.
摘要: This article reports the genetic and pathogenic characteristics of 34 isolates of H6N1 avian influenza viruses isolated in Taiwan between 1972 and 2005. Genetic analyses showed that a unique lineage of H6N1 viruses has been established in domestic chickens in Taiwan since 1997, and this lineage of viruses differs from the H6N1 viruses circulating in Hong Kong and Southeastern China. Pathogenicity tests showed that all Taiwanese H6N1 viruses were of low pathogenicity but might lead to economic loss when associated with other diseases. Hemagglutination inhibition tests showed that antigenic drift has Occurred in Taiwanese H6N1 viruses, and sequence comparison has identified a total of five possible antigenic sites oil the hemagglutinin molecule of the H6N1 viruses. Some Taiwanese H6N1 viruses could replicate in mice without preadaptation, indicating that these viruses have the potential to cause cross-species infection into mammals.
URI: http://hdl.handle.net/11455/66625
ISSN: 0005-2086
文章連結: http://dx.doi.org/10.1637/7640-050106r.1
Appears in Collections:微生物暨公共衛生學研究所

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