Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/66673
DC FieldValueLanguage
dc.contributor.authorChang, C.C.en_US
dc.contributor.author張照勤zh_TW
dc.contributor.authorTsai, M.H.en_US
dc.contributor.authorLiao, J.W.en_US
dc.contributor.authorChan, J.P.W.en_US
dc.contributor.authorWong, M.L.en_US
dc.contributor.authorChang, S.C.en_US
dc.contributor.author廖俊旺zh_TW
dc.contributor.author陳鵬文zh_TW
dc.contributor.author王孟亮zh_TW
dc.contributor.author張仕杰zh_TW
dc.date2009zh_TW
dc.date.accessioned2014-06-11T05:46:57Z-
dc.date.available2014-06-11T05:46:57Z-
dc.identifier.issn0003-1488zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/66673-
dc.description.abstractObjective-To evaluate the prognostic potential of expression of hormone receptors in malignant mammary gland tumors of dogs. Design-Cohort study. Animals-89 female dogs with malignant mammary gland tumors and 24 female dogs with benign mammary gland tumors. Procedures-Female dogs with malignant (n = 89 dogs) and benign (24) mammary gland tumors were evaluated to determine the prognostic value of the expression of estrogen receptor (ER)alpha or the progesterone receptor (PR), as determined by use of immunohistochemical methods. Results-In this study, 68 (60.2%) and 88 (779%) of the 113 dogs with mammary gland tumors had expression of ER alpha and PR, respectively. Expression of ER alpha and PR was detected proportionately more frequently in benign tumors (23/24 (95.8%] and 24/24 [100%], respectively) than in malignant tumors (45/89 [50.6%] and 64/89 [71.9%]). Percentage of tumors with positive results for ER alpha and PB was significantly higher in tumors < 5 cm in diameter; as clinical stage I, II or III; and without metastasis to lymph nodes or distant metastasis. However, only PR expression in tumor cells was significantly associated with 1-year survival after surgical removal of the tumor. Moreover, dogs with malignant tumors expressing ER alpha and PR had a significantly higher survival rate, compared with the rate for dogs with malignant tumors expressing ER alpha but not PR. Conclusions and Clinical Relevance-These findings strongly suggested that expression of PR could be used as a prognostic factor for survival, especially in female dogs with malignant mammary gland tumors with ERa expression. (J Am Vet Med Assoc 2009;235:391-396)en_US
dc.language.isoen_USzh_TW
dc.relationJavma-Journal of the American Veterinary Medical Associationen_US
dc.relation.ispartofseriesJavma-Journal of the American Veterinary Medical Association, Volume 235, Issue 4, Page(s) 391-396.en_US
dc.subjectbreast-canceren_US
dc.subjectestrogen-receptoren_US
dc.subjectsteroid-receptorsen_US
dc.subjectalphaen_US
dc.subjectprognosisen_US
dc.subjectcarcinomaen_US
dc.subjecttherapyen_US
dc.subjecthosten_US
dc.subjectbetaen_US
dc.titleEvaluation of hormone receptor expression for use in predicting survival of female dogs with malignant mammary gland tumorsen_US
dc.typeJournal Articlezh_TW
Appears in Collections:微生物暨公共衛生學研究所
文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.