Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/67706
標題: The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
作者: Wang, Y.
Ding, Q.Q.
Yen, C.J.
Xia, W.Y.
Izzo, J.G.
Lang, J.Y.
Li, C.W.
Hsu, J.L.
Miller, S.A.
Wang, X.M.
Lee, D.F.
Hsu, J.M.
Huo, L.F.
LaBaff, A.M.
Liu, D.P.
Huang, T.H.
Lai, C.C.
Tsai, F.J.
Chang, W.C.
Chen, C.H.
Wu, T.T.
Buttar, N.S
關鍵字: esophageal cancer
gastric-cancer
tuberous sclerosis
cell-survival
mtor
mechanisms
gli1
activation
target
growth
期刊/報告no:: Cancer Cell, Volume 21, Issue 3, Page(s) 374-387.
摘要: Esophageal adenocarcinoma (EAC) is the most prevalent esophageal cancer type in the United States. The TNF-alpha/mTOR pathway is known to mediate the development of EAC. Additionally, aberrant activation of Gli1, downstream effector of the Hedgehog (HH) pathway, has been observed in EAC. In this study, we found that an activated mTOR/S6K1 pathway promotes Gli1 transcriptional activity and oncogenic function through S6K1-mediated Gli1 phosphorylation at Ser84, which releases Gli1 from its endogenous inhibitor, SuFu. Moreover, elimination of S6K1 activation by an mTOR pathway inhibitor enhances the killing effects of the HH pathway inhibitor. Together, our results established a crosstalk between the mTOR/S6K1 and HH pathways, which provides a mechanism for SMO-independent Gli1 activation and also a rationale for combination therapy for EAC.
URI: http://hdl.handle.net/11455/67706
ISSN: 1535-6108
文章連結: http://dx.doi.org/10.1016/j.ccr.2011.12.028
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