Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/67859
標題: Trilinolein Inhibits Proliferation of Human Non-Small Cell Lung Carcinoma A549 Through the Modulation of PI3K/Akt Pathway
作者: Chou, P.Y.
Huang, G.J.
Pan, C.H.
Chien, Y.C.
Chen, Y.Y.
Wu, C.H.
Sheu, M.J.
Cheng, H.C.
關鍵字: Chinese Herbs
Panax notoginseng
Apoptosis
Trilinolein
PI3K/Akt
neonatal-rat cardiomyocytes
panax-notoginseng
cancer-cells
superoxide-dismutase
gene-expression
target
identification
mechanism
apoptosis
growth
期刊/報告no:: American Journal of Chinese Medicine, Volume 39, Issue 4, Page(s) 803-815.
摘要: Trilinolein has been identified as one of the active constituents isolated from Panax notoginseng used widely in traditional Chinese medicine. Protective actions of Panax notoginseng against cerebral ischemia, beneficial effects on the cardiovascular system, and hemostatic, antioxidant, hypolipidemic, hepatoprotective, renoprotective and estrogen-like activities have been illustrated. In the present study, the effects of trilinolein on the growth of non-small cell lung carcinoma A549 were investigated. It was found that the exposure of A549 cells to trilinolein resulted in the growth inhibition and the induction of apoptosis in a dose- and time- dependent manner. Trilinolein treatment induced the upregulation of proapoptotic Bax, downregulation of anti-apoptotic Bcl-2 expression, which was associated with the proteolytic activation of caspases and the concomitant degradation of poly(ADP-ribose) polymerase (PARP) protein. Intracellular reactive oxygen species seem to play a role in the trilinolein-induced apoptosis, since ROS were produced early in the trilinolein treatment. Moreover, the activity of PI3K/Akt was downregulated in trilinolein-treated cells. Our results demonstrated that the most important regulators of trilinolein-induced apoptosis are Bcl-2 family and caspase-3, which are associated with cytochrome c release and dephosphorylation on the Akt signaling pathway.
URI: http://hdl.handle.net/11455/67859
ISSN: 0192-415X
文章連結: http://dx.doi.org/10.1142/s0192415x11009214
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