請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/67952
標題: Berberine Induced Apoptosis via Promoting the Expression of Caspase-8,-9 and-3, Apoptosis-inducing Factor and Endonuclease G in SCC-4 Human Tongue Squamous Carcinoma Cancer Cells
作者: Ho, Y.T.
Lu, C.C.
Yang, J.S.
Chiang, J.H.
Li, T.C.
Ip, S.W.
Hsia, T.C.
Liao, C.L.
Lin, J.G.
Wood, W.G.
Chung, J.G.
關鍵字: Berberine
apoptosis
caspase
SCC-4 cells
AIF
EndoG
upper aerodigestive tract
human hepatoma-cells
ca ski cells
oral-cavity
cycle arrest
mitochondrial pathway
inhibits growth
a-549
cells
in-vitro
risk
期刊/報告no:: Anticancer Research, Volume 29, Issue 10, Page(s) 4063-4070.
摘要: Many phytochemicals have been recognized to have potential chemopreventive or chemotherapeutic efficacy in cancer treatment. In this study, we hypothesized that berberine would have anticancer activities in SCC-4 human tongue cancer cells. Results indicated that berberine reduced the viability of SCC-4 cells, which was initiated by the generation of reactive oxygen species, via an increase in cytosolic Ca(2+). Berberine-induced apoptosis was associated with a reduction of the mitochondrial membrane potential associated with changes in the Bax/Bcl-2 ratio, release of cytochrome c from mitochondria and activation of down stream caspase-3. Real-time PCR showed that berberine stimulated gene expression of caspase-8, -9 and 3, apoptosis-inducing factor and endonuclease G. The present study demonstrated that berberine-mediated apoptosis of SCC-4 cells is regulated by ROS, mitochondria, caspase-3-dependent and mitochondria-dependent pathways, suggesting that berberine may be considered for future studies as a promising therapeutic candidate for human tongue cancer.
URI: http://hdl.handle.net/11455/67952
ISSN: 0250-7005
顯示於類別:期刊論文

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。