Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68190
標題: Indenopyridine hydrochloride induced testicular spermatogenesis failure with high seminal alkaline phosphatase levels in male dog
作者: Chang, C.L.T.
Fung, H.P.
Lin, Y.F.
Kuo, C.Y.
Chien, C.W.
關鍵字: indenopyridine hydrochloride
spermatogenesis
alkaline phosphatase
male dog
期刊/報告no:: Biological & Pharmaceutical Bulletin, Volume 25, Issue 8, Page(s) 1097-1100.
摘要: Indenopyridine hydrochloride (IH), an antispermatogenic agent, was tested to determine the testicular pathological changes, seminal spermatozoa concentrations and seminal plasma alkaline phosphatase levels in male dogs. A single oral dosage of 30 mg IH/kg BW induced the dissociation and premature release of germ cells into the lumens of seminiferous tubules. Ring-shaped spermatid nuclei, nuclear pykonosis of spermatocytes and multinucleated cell associations were also observed. Thereafter, the spermatogenic index (SI) significantly decreased one day after IH administration. Moreover, seminal spermatozoa concentrations decreased two weeks after drug treatment; and there was a statistically significant difference in spermatozoa production inhibited by IH compared to the control. Reversible spermatogenesis was noted 7 weeks after IH treatment in male dogs. Meanwhile, seminal plasma alkaline phosphatase levels also significantly increased two weeks after IH treatment. These data confirm that IH might induce a two-month inhibition of spermatogenesis in male dogs.
URI: http://hdl.handle.net/11455/68190
ISSN: 0918-6158
文章連結: http://dx.doi.org/10.1248/bpb.25.1097
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