Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68230
標題: A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates
作者: Lin, G.L.
Tseng, H.C.
Chio, A.C.
Tseng, T.M.
Tsai, B.Y.
關鍵字: structure-reactivity relationships
cholesterol esterase
human
butyrylcholinesterase
cholinesterase-inhibitors
highly potent
binding
site
hydrolysis
kinetics
recognition
期刊/報告no:: Bioorganic & Medicinal Chemistry Letters, Volume 15, Issue 4, Page(s) 951-955.
摘要: Alkane-1-N-butylcarbamate-n-ols (1-7) and 1,n-alkane-di-N-butylcarbamates (8-14) are potent pseudo-substrate inhibitors of acetylcholinesterase. For inhibitors 1-7, the pre-steady state -logK(s) values and steady state -logK(i), values are linearly correlated with the tether length (N). However, for inhibitors 8-14, correlation of the -logK(s) or -logK(i) values against N deviates from linearity. A discontinuity of the -logK(s) versus N plot, concave downwards, is indicative of a rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by inhibitors 8-14. (C) 2004 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/68230
ISSN: 0960-894X
文章連結: http://dx.doi.org/10.1016/j.bmcl.2004.12.058
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