Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68230
DC FieldValueLanguage
dc.contributor.authorLin, G.L.en_US
dc.contributor.authorTseng, H.C.en_US
dc.contributor.authorChio, A.C.en_US
dc.contributor.authorTseng, T.M.en_US
dc.contributor.authorTsai, B.Y.en_US
dc.date2005zh_TW
dc.date.accessioned2014-06-11T05:56:28Z-
dc.date.available2014-06-11T05:56:28Z-
dc.identifier.issn0960-894Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68230-
dc.description.abstractAlkane-1-N-butylcarbamate-n-ols (1-7) and 1,n-alkane-di-N-butylcarbamates (8-14) are potent pseudo-substrate inhibitors of acetylcholinesterase. For inhibitors 1-7, the pre-steady state -logK(s) values and steady state -logK(i), values are linearly correlated with the tether length (N). However, for inhibitors 8-14, correlation of the -logK(s) or -logK(i) values against N deviates from linearity. A discontinuity of the -logK(s) versus N plot, concave downwards, is indicative of a rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by inhibitors 8-14. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry Letters, Volume 15, Issue 4, Page(s) 951-955.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.bmcl.2004.12.058en_US
dc.subjectstructure-reactivity relationshipsen_US
dc.subjectcholesterol esteraseen_US
dc.subjecthumanen_US
dc.subjectbutyrylcholinesteraseen_US
dc.subjectcholinesterase-inhibitorsen_US
dc.subjecthighly potenten_US
dc.subjectbindingen_US
dc.subjectsiteen_US
dc.subjecthydrolysisen_US
dc.subjectkineticsen_US
dc.subjectrecognitionen_US
dc.titleA rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamatesen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.bmcl.2004.12.058zh_TW
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