Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68295
標題: Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas)
作者: Cheng, C.H.
陳鴻震
Yu, K.C.
Chen, H.L.
Chen, S.Y.
Huang, C.H.
Chan, P.C.
Wung, C.W.
Chen, H.C.
關鍵字: Src
Crk-associated substrate
Src homology 3 domain
tumor
anoikis
invasion
focal adhesion kinase
cell-migration
induced apoptosis
tyrosine
kinase
direct binding
p130(cas)
protein
transformation
survival
growth
期刊/報告no:: Febs Letters, Volume 557, Issue 1-3, Page(s) 221-227.
摘要: Crk-associated substrate (Cas) is highly phosphorylated by v-Src and plays a critical role in v-Src-induced cell transformation. In this study, we found that the Src homology (SH) 3 domain of Cas blocked v-Src-stimulated anchorage-independent cell growth, Matrigel invasion, and tumor growth in nude mice. Biochemical analysis revealed that the Cas SH3 domain selectively inhibited v-Src-stimulated activations of AKT and JNK, but not ERK and STAT3. Attenuation of the AKT pathway by the Cas SH3 domain rendered v-Src-transformed cells susceptible to apoptosis. Inhibition of the JNK pathway by the Cas SH3 domain led to suppression of v-Src-stimulated invasion. Taken together, our results indicate that the Cas SH3 domain has an anti-tumor function, which severely impairs the transforming potential of v-Src. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/11455/68295
ISSN: 0014-5793
文章連結: http://dx.doi.org/10.1016/s0014-5793(03)01501-1
Appears in Collections:生命科學院

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.