Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68301
標題: Polyphenol Extracts from Hibiscus sabdariffa Linnaeus Attenuate Nephropathy in Experimental Type 1 Diabetes
作者: Lee, W.C.
陳鴻震
Wang, C.J.
Chen, Y.H.
Hsu, J.D.
Cheng, S.Y.
Chen, H.C.
Lee, H.J.
關鍵字: Hibiscus sabdariffa L.
polyphenols
diabetic nephropathy
oxidative
stress
low-density-lipoprotein
complications
cells
atherosclerosis
apoptosis
phosphorylation
cholesterol
expression
oxidation
mellitus
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 57, Issue 6, Page(s) 2206-2210.
摘要: Diabetic nephropathy progressed to end-stage renal disease (ESRD) is found in type 1 or type 2 diabetes. Oxidative stress is one of the precipitation factors in diabetic nephropathy. Previously, Hibiscus sabdariffa Linnaeus and its polyphenol extracts were found to possess antioxidative effects. This study is aimed to investigate the effect of Hibiscus sabdariffa L. polyphenol extract (HPE) in streptozotocin (STZ) induced diabetic nephropathy. The results show that HPE reduced kidney mass induced by STZ significantly, as well as improving hydropic change of renal proximal convoluted tubules in the rats. HPE also significantly reduced serum triglyceride, total cholesterol and LDL in STZ induced rats. Treatment with HPE significantly increased the activity of catalase and glutathione and reduced lipid peroxidation (thiobarbituric acid-reactive substances, TBARS). The findings of this research show the beneficial effects of HPE on STZ induced diabetic nephropathy including pathology, serum lipid profile and oxidative marker in kidney.
URI: http://hdl.handle.net/11455/68301
ISSN: 0021-8561
文章連結: http://dx.doi.org/10.1021/jf802993s
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