Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68344
標題: Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
作者: Chen, S.Y.
陳鴻震
Chen, H.C.
關鍵字: receptor tyrosine kinase
c-met
ferm domain
oncogenic rearrangement
terminal domain
protein
gab1
phosphorylation
activation
motility
期刊/報告no:: Molecular and Cellular Biology, Volume 26, Issue 13, Page(s) 5155-5167.
摘要: Focal adhesion kinase (FAK) has been implicated to be a point of convergence of integrin and growth factor signaling pathways. Here we report that FAK directly interacts with the hepatocyte growth factor receptor c-Met. Phosphorylation of c-Met at Tyr-1349 and, to a lesser extent, Tyr-1356 is required for its interaction with the band 4.1 and ezrin/radixin/moesin homology domain (FERM domain) of FAK. The F2 subdomain of the FAK FERM domain alone is sufficient for Met binding, in which a patch of basic residues ((216)KAKTLRK(222)) are critical for the interaction. Met-FAK interaction leads to FAK activation and subsequent contribution to hepatocyte growth factor-induced cell motility and cell invasion. Our results provide evidence that constitutive Met-FAK interaction may be a critical determinant for tumor cells to acquire invasive potential.
URI: http://hdl.handle.net/11455/68344
ISSN: 0270-7306
文章連結: http://dx.doi.org/10.1128/mcb.02186-05
Appears in Collections:生命科學院

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.