Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68616
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dc.contributor.authorWu, H.P.en_US
dc.contributor.authorShih, C.C.en_US
dc.contributor.authorLin, C.Y.en_US
dc.contributor.authorHua, C.C.en_US
dc.contributor.authorChuang, D.Y.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-11T05:57:05Z-
dc.date.available2014-06-11T05:57:05Z-
dc.identifier.issn1466-609Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68616-
dc.description.abstractIntroduction: Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sought to determine the mechanisms of immune suppression in severe sepsis by repeated detection. Methods: We designed this prospective observational study to measure monocyte human leukocyte antigen (HLA)-DR expression, plasma cytokine levels and cytokine responses on days 1 and 7 in stimulated peripheral blood mononuclear cells (PBMCs) of healthy controls and patients with severe sepsis. Results: Of the 35 enrolled patients, 23 survived for 28 days and 12 died, 6 of whom died within 7 days. Plasma levels of IL-1 beta, IL-6, IL-10, IL-17, transforming growth factor (TGF)-beta 1 and TNF-alpha were higher, but plasma IL-12 level was lower in septic patients than those in controls. Day 1 plasma levels of IL-1 beta, IL-6, IL-10 and TGF-beta 1 in nonsurvivors were higher than those in survivors. Day 7 plasma IL-10 levels in nonsurvivors were higher than in survivors. IL-1 beta response was higher, but IL-12 and TNF-alpha responses were lower in septic patients than in controls. Day 1 IL-6 response was lower, but day 1 TGF-beta 1 response was higher in nonsurvivors than in survivors. Plasma IL-6 and IL-10 levels were decreased in survivors after 6 days. IL-6 response was decreased in survivors after 6 days, but IL-12 response was increased. Monocyte percentage was higher, but positive HLA-DR percentage in monocytes and mean fluorescence intensity (MFI) of HLA-DR were lower in septic patients than in controls. MFI of HLA-DR was increased in survivors after 6 days. Conclusions: Monocyte HLA-DR expression and IL-12 response from PBMCs are restored in patients who survive severe sepsis.en_US
dc.language.isoen_USzh_TW
dc.relationCritical Careen_US
dc.relation.ispartofseriesCritical Care, Volume 15, Issue 5.en_US
dc.relation.urihttp://dx.doi.org/10.1186/cc10464en_US
dc.subjectinterleukin 12en_US
dc.subjectinterleukin 6en_US
dc.subjecthuman leukocyte antigen-DRen_US
dc.subjectperipheralen_US
dc.subjectblood mononuclear cellsen_US
dc.subjectsevere sepsisen_US
dc.subjectseptic shocken_US
dc.subjectdisease severityen_US
dc.subjectantiinflammatory cytokinesen_US
dc.subjectinterleukin-10en_US
dc.subjectmanagementen_US
dc.subjectassociationen_US
dc.subjectguidelinesen_US
dc.subjectcampaignen_US
dc.subjectreceptoren_US
dc.titleSerial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivorsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1186/cc10464zh_TW
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