Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68666
標題: Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet
作者: Shih, C.C.
Lin, C.H.
Lin, W.L.
關鍵字: Momordica charantia
insulin resistance
resistin
leptin
activated receptor-alpha
peroxisome proliferator
adipose-tissue
c57bl/6j mice
hypoglycemic activity
metabolic diseases
glucose-tolerance
plasma leptin
body-weight
rats
期刊/報告no:: Diabetes Research and Clinical Practice, Volume 81, Issue 2, Page(s) 134-143.
摘要: We examined the preventive effect of Momordica charantia L. fruit (bitter melon) on hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat (HF) diet. Firstly, mice were divided randomly into two groups: the control group was fed low-fat (LF) diet, whereas the experimental group was fed with a 45% HF diet last for 12 weeks. After 8 week of induction, the HF group was subdivided into six groups and was given orally with or without M. charantia or rosiglitazone 4 weeks afterward. We demonstrated that bitter melon was effective in ameliorating the HF diet-induced hyperglycemia, hyperleptinemia, and decreased the levels of blood glycated hemoglobin (HbA1c) and free fatty acid (FFA) (P < 0.01, P < 0.05, P < 0.05, respectively), whereas increased the adipose PPAR gamma and liver PPAR alpha mRNA levels. Additionally, bitter melon significantly decreased the weights of epididymal white adipose tissue and visceral fat, and decreased the adipose leptin and resistin mRNA levels. It is tempting to speculate that at least a portion of bitter melon effects is due to be through PPAR gamma-mediated pathways, resulting in lowering glucose levels and improving insulin resistance, and partly be through PPAR alpha-mediated pathways to improve plasma lipid profiles. This is the first report demonstrating that bitter melon, is a food factor, but not a medicine, itself could influence dual PPAR alpha/PPAR gamma expression and the mediated gene expression, is effective in ameliorating insulin resistance and visceral obesity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/68666
ISSN: 0168-8227
文章連結: http://dx.doi.org/10.1016/j.diabres.2008.04.023
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