Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68826
標題: Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse
作者: Chen, H.Y.
Wan, L.
Chung, Y.W.
Chen, W.C.
Tsai, F.J.
Tsai, C.H.
關鍵字: pelvic organ prolapse
estrogen receptor beta gene polymorphism
haplotype
urinary-incontinence
cesarean-section
floor disorders
ligaments
期刊/報告no:: European Journal of Obstetrics Gynecology and Reproductive Biology, Volume 138, Issue 1, Page(s) 105-109.
摘要: Objective: Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor beta (ER beta) gene polymorphisms were associated with POP by conducting a case-control association study in 69 women with POP and 141 women without POP. Study design: Genotypes of the ER beta gene polymorphisms (rs2987983, rs1271572, rs944459, rs1256049, and rs1255998) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. Haplotyping analysis was used to determine the relationship among five polymorphisms in the ER beta gene and POP. Results: There was no significant difference between women with and those without POP in the distribution of any of the genotypes evaluated. In haplotype frequency estimation analysis, haplotype CGCGC was more prevalent in women with POP (16.7%) than in women without POP (8.9%) (p = 0.011). Using multivariable logistic regression, age, parity and haplotype CGCGC were significantly associated with POP. Conclusion: Although the sample size of women with POP studied is small, the present study shows that ER beta gene haplotype may be associated with POP. (c) 2008 Published by Elsevier Ireland Ltd.
URI: http://hdl.handle.net/11455/68826
ISSN: 0301-2115
文章連結: http://dx.doi.org/10.1016/j.ejogrb.2007.12.013
Appears in Collections:期刊論文

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.