Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68859
標題: Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3 gamma in an Experimental Animal Model
作者: Wang, S.C.
Lee, S.F.
Wang, C.J.
Lee, C.H.
Lee, W.C.
Lee, H.J.
關鍵字: protein-kinase-b
chronic kidney-disease
nf-kappa-b
glut4
translocation
mesangial cells
dried calyx
akt
rats
stress
activation
期刊/報告no:: Evidence-Based Complementary and Alternative Medicine, Page(s) 1-9.
摘要: Several studies point out that oxidative stress maybe a major culprit in diabetic nephropathy. Aqueous extract of Hibiscus sabdariffa L. (HSE) has been demonstrated as having beneficial effects on anti-oxidation and lipid-lowering in experimental studies. This study aimed at investigating the effects of Hibiscus sabdariffa L. on diabetic nephropathy in streptozotocin induced type 1 diabetic rats. Our results show that HSE is capable of reducing lipid peroxidation, increasing catalase and glutathione activities significantly in diabetic kidney, and decreasing the plasma levels of triglyceride, low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL) value. In histological examination, HSE improves hyperglycemia-caused osmotic diuresis in renal proximal convoluted tubules (defined as hydropic change) in diabetic rats. The study also reveals that up-regulation of Akt/Bad/14-3-3 gamma and NF-kappa B-mediated transcription might be involved. In conclusion, our results show that HSE possesses the potential effects to ameliorate diabetic nephropathy via improving oxidative status and regulating Akt/Bad/14-3-3 gamma signaling.
URI: http://hdl.handle.net/11455/68859
ISSN: 1741-427X
文章連結: http://dx.doi.org/10.1093/ecam/nep181
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