Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69032
標題: Leptin in relation to hepatocellular carcinoma in patients with liver cirrhosis
作者: Wang, Y.Y.
Lin, S.Y.
關鍵字: cirrhosis
fat mass
hepatocellular carcinoma
leptin
alcoholic cirrhosis
energy-expenditure
insulin resistance
virus-infection
growth-factor
hepatitis-b
cell-line
c virus
receptor
rat
期刊/報告no:: Hormone Research, Volume 60, Issue 4, Page(s) 185-190.
摘要: Objectives: This study was conducted to investigate whether leptin is involved in the etiogenesis of hepatocellular carcinoma (HCC) in cirrhotic patients. Methods: Thirty-one male cirrhotic patients with HCC, 26 male cirrhotic patients without HCC, and 25 control subjects were included in this study. Body fat mass (FM) was determined by bioelectrical impedance analysis, and serum leptin and hormone concentrations were measured by immunoassay. Results: A significant correlation of serum leptin levels to FM was observed in both patient groups and control subjects (r = 0.760, p < 0.001; r = 0.520, p < 0.01; r = 0.460, p < 0.05, respectively). The serum leptin levels in cirrhotic patients with or without HCC were significantly higher than those in control subjects (6.0 +/- 1.1 vs. 6.1 +/- 0.6 vs. 3.8 +/- 0.3 ng/ml, p < 0.05), though their body FM was lower. Using a multiple logistic regression analysis, it was found that the odds ratio of serum leptin for HCC was 1.04 (95% CI 0.79-1.33) after adjustment of several known risk factors. Conclusions: Our study demonstrated that cirrhotic patients with or without HCC had increased serum leptin concentrations. However, leptin did not appear to be associated with the development of HCC in cirrhotic patients. Copyright (C) 2003 S. Karger AG, Basel.
URI: http://hdl.handle.net/11455/69032
ISSN: 0301-0163
文章連結: http://dx.doi.org/10.1159/000073231
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