請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/69295
標題: Antagonistic activity against Helicobacter pylori infection in vitro by a strain of Enterococcus faecium TM39
作者: Tsai, C.C.
Huang, L.F.
Lin, C.C.
Tsen, H.Y.
關鍵字: Enterococcus faecium
Helicobacter pylori
adhesion
urease
intestinal-cell lines
lactic-acid bacteria
lactobacillus-acidophilus
humans
bifidobacterium
adherence
translocation
environment
invasion
survival
期刊/報告no:: International Journal of Food Microbiology, Volume 96, Issue 1, Page(s) 1-12.
摘要: Lactic acid bacteria (LAB) strains from infant feces were screened for anti-Helicobacter pylori use. In the beginning, we selected the strains based on their capability to adhere to the human intestinal epithelial cell (Int-407), colonial enterocyte-like Caco-2 cell, human cervical epithelioid carcinoma cell (HeLa), and human gastric carcinoma cell (TSGH 9201). Then, acid and bile salt tolerance of these LAB strains was evaluated. In addition, the ability of these LAB strains to inhibit the growth of H. pylori and to expel H. pylori cells from TSGH 9201 were studied. The spent culture supernatant (SCS) of a selected strain TM39, i.e., TM39-SCS, significantly inhibited the viability of H. pylori in vitro. It also inhibited the urease activity of H. pylori in vitro. For these antagonistic effects, in addition to pH and lactic acid, some factors in TM39-SCS might play the major role. Treatment of H. pylori with the SCS or cells of strain TM39 significant reduced its binding to TSGH 9201 cells. Although strain TM39 is identified as Enterococcus faecium, it is not vancomycin resistant and is proved to be safe through the invasion study and a 28-day feeding study with Wistar rats. (C) 2004 Published by Elsevier B.V.
URI: http://hdl.handle.net/11455/69295
ISSN: 0168-1605
文章連結: http://dx.doi.org/10.1016/j.ijfoodmicro.2003.10.019
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