Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69356
標題: Effects of short- and long-term hypobaric hypoxia on Bcl2 family in rat heart
作者: Lee, S.D.
Kuo, W.W.
Wu, C.H.
Lin, Y.M.
Lin, J.A.
Lu, M.C.
Yang, A.L.
Liu, J.Y.
Wang, S.G.P.
Liu, C.J.
Chen, L.M.
Huang, C.Y.
關鍵字: cardiac
cell death
hypobaric hypoxia
mitochondrial
time course
high-altitude hypoxia
open-artery hypothesis
cardiac myocytes
protein
family
cytochrome-c
apoptosis
disease
brain
death
myocardium
期刊/報告no:: International Journal of Cardiology, Volume 108, Issue 3, Page(s) 376-384.
摘要: Background: Controversial effects of intermittent hypobaric hypoxia such as cardiac damage or cardiac protection are still mysterious. It is unclear if short-term and long-term intermittent hypobaric hypoxic challenges exert different effects on cytochrome c oxidase and Bcl-2 family in rat heart. Methods: Sixty Sprague-Dawley rats were randomized assigned into two groups: first, short-term intermittent hypobaric hypoxia (STIHH)-nonnobaric nonnoxia (n = 10), hypobaric hypoxia (380 mmHg, 12% O-2, 8 hr/day) for I day (n = 10), and for 4 days (n = 10) and second, long-term intermittent hypobaric hypoxia (LTIHH)-normobaric normoxia, (n=10), hypobaric hypoxia for I week (n=10) and 2 weeks (n = 10). After STIHH or LTIHH challenge, myocardial morphology, cytochrome c oxidase and pro-apoptotic Bcl-2 family in the excised left ventricle were determined by histological analysis, Western blotting, and RT-PCR. Results: Increased wall thickness and abnormal myocardial architecture were observed after LTIHH. Cytochrome c oxidase and antiapoptotic Bcl-2 protein were significantly increased after STIHH, but were decreased after LTIHH. Pro-apoptotic BNIP3 and Bad proteins were significantly decreased after STIHH but increased after LTIHH. Conclusions: STIHH appeared to exert protective effects on hearts whereas LTIHH appeared to exert deleterious effects, which imply that deleterious or advantageous effect of cardiac adaptation after intermittent hypobaric hypoxia is tightly time-course dependent. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/69356
ISSN: 0167-5273
文章連結: http://dx.doi.org/10.1016/j.ijcard.2005.05.046
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