Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69400
標題: ATPase family AAA domain containing 3A is an anti-apoptotic factor and a secretion regulator of PSA in prostate cancer
作者: Huang, K.H.
Chow, K.C.
Chang, H.W.
Lin, T.Y.
Lee, M.C.
期刊/報告no:: International Journal of Molecular Medicine, Volume 28, Issue 1, Page(s) 9-15.
摘要: In order to investigate the clinical value of ATPase family AAA domain containing 3A (ATAD3A), a potential anti-apoptotic factor in prostate cancer (PCa), immunohistochemistry was used to measure ATAD3A expression in pathological specimens from 86 Chinese patients and in 183 tissue-array samples from American patients. The effect of ATAD3A on the expression of prostate specific antigen (PSA) and drug resistance in PCa cell lines was determined by in vitro experiments. ATAD3A was detected in 74 of 86 (86.0%) Chinese specimens and in 145 of 183 (79.2%) American patient samples. No difference was found in ATAD3A expression between these two patient groups. In vitro, silencing of ATAD3A expression reduced PSA secretion and cisplatin resistance, suggesting that ATAD3A was associated with PSA secretion and drug resistance in PCa.
URI: http://hdl.handle.net/11455/69400
ISSN: 1107-3756
文章連結: http://dx.doi.org/10.3892/ijmm.2011.670
Appears in Collections:期刊論文

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.