Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69411
DC FieldValueLanguage
dc.contributor.authorYu, F.S.en_US
dc.contributor.authorYang, J.S.en_US
dc.contributor.authorYu, C.S.en_US
dc.contributor.authorLu, C.C.en_US
dc.contributor.authorChiang, J.H.en_US
dc.contributor.authorLin, C.W.en_US
dc.contributor.authorChung, J.G.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-11T05:58:17Z-
dc.date.available2014-06-11T05:58:17Z-
dc.identifier.issn0022-0345zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/69411-
dc.description.abstractPhytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. Safrole decreased the percentage of viable HSC-3 cells via induction of apoptosis by an increased level of cytosolic Ca(2+) and a reduction in the mitochondrial membrane potential (Delta Psi(m)). Changes in the membrane potential were associated with changes in the Bax, release of cytochrome c from mitochondria, and activation of downstream caspases-9 and -3, resulting in apoptotic cell death. In vivo studies also showed that safrole reduced the size and volume of an HSC-3 solid tumor on a xenograft athymic nu/nu mouse model. Western blotting and flow cytometric analysis studies confirmed that safrole-mediated apoptotic cell death of HSC-3 cells is regulated by cytosolic Ca(2+) and by mitochondria-and Fas-dependent pathways.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Dental Researchen_US
dc.relation.ispartofseriesJournal of Dental Research, Volume 90, Issue 2, Page(s) 168-174.en_US
dc.relation.urihttp://dx.doi.org/10.1177/0022034510384619en_US
dc.subjectsafroleen_US
dc.subjectoral cancer HSC-3 cellsen_US
dc.subjectapoptosisen_US
dc.subjectcaspase cascadesen_US
dc.subjectxenograften_US
dc.subjectmodelen_US
dc.subjectupper aerodigestive tracten_US
dc.subjectmitochondria-dependent pathwaysen_US
dc.subjectendoplasmic-reticulum stressen_US
dc.subjectdna-adductsen_US
dc.subjectalcohol-consumptionen_US
dc.subjectactivation pathwayen_US
dc.subjecttongue canceren_US
dc.subjectscc-4 cellsen_US
dc.subjectin-vitroen_US
dc.subjectrisken_US
dc.titleSafrole Induces Apoptosis in Human Oral Cancer HSC-3 Cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1177/0022034510384619zh_TW
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