請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/69698
標題: Immunomagnetic reduction assay using high-T-c superconducting-quantum-interference-device-based magnetosusceptometry
作者: Chieh, J.J.
Yang, S.Y.
Horng, H.E.
Yu, C.Y.
Lee, C.L.
Wu, H.L.
Hong, C.Y.
Yang, H.C.
關鍵字: magnetic nanoparticles
squid
immunoassay
期刊/報告no:: Journal of Applied Physics, Volume 107, Issue 7.
摘要: Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3340861]
URI: http://hdl.handle.net/11455/69698
ISSN: 0021-8979
文章連結: http://dx.doi.org/10.1063/1.3340861
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