Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69974
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dc.contributor.authorLin, W.H.en_US
dc.contributor.authorLin, C.K.en_US
dc.contributor.authorSheu, S.J.en_US
dc.contributor.authorHwang, C.F.en_US
dc.contributor.authorYe, W.T.en_US
dc.contributor.authorHwang, W.Z.en_US
dc.contributor.authorTsen, H.Y.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-11T05:59:11Z-
dc.date.available2014-06-11T05:59:11Z-
dc.identifier.issn0022-1147zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/69974-
dc.description.abstractWe investigated the bactericidal activity and exclusion effect of 10 strains of lactic acid bacteria (LAB) isolated from different commercial food products and infant feces against Helicobacter pylori (H. pylori) in human gastric epithelial AGS cells. Antagonistic activity of spent culture supernatants (SCS) from LAB(LAB-SCS) was tested, and the content of organic acids in SCS was analyzed with high-performance liquid chromatography (HPLC). In addition, the bactericidal activities of LAB-SCS were estimated by a time-kill assay and by measuring the exclusion effect of LAB-SCS against H. pylori in AGS cells. The results showed that SCS from certain strains with higher concentrations of organic acids dramatically decreased the viability of H. pylori. We also proved that the organic acids could inhibit H. pylori adhesion and invasion of AGS cells. Furthermore, the concentration and speciation of organic acids in SCS after fermentation of LAB are important factors in the inhibition of H. pylori infection. In addition, the in vitro methods used in this study might provide for the rapid screening of potential probiotics with anti-H. pylori activity in the dairy industry.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Food Scienceen_US
dc.relation.ispartofseriesJournal of Food Science, Volume 74, Issue 6, Page(s) M225-M230.en_US
dc.relation.urihttp://dx.doi.org/10.1111/j.1750-3841.2009.01194.xen_US
dc.subjectbactericidal activityen_US
dc.subjectexclusionen_US
dc.subjectHelicobacter pylorien_US
dc.subjectLAB-SCSen_US
dc.subjectlacticen_US
dc.subjectacid bacteriaen_US
dc.subjectin-vitro inhibitionen_US
dc.subjectlactobacillus-acidophilusen_US
dc.subjectorganic-acidsen_US
dc.subjectprobioticsen_US
dc.subjectstrainen_US
dc.subjectvivoen_US
dc.subjectepidemiologyen_US
dc.subjecteradicationen_US
dc.subjectsalivariusen_US
dc.subjectproductsen_US
dc.titleAntagonistic Activity of Spent Culture Supernatants of Lactic Acid Bacteria against Helicobacter Pylori Growth and Infection in Human Gastric Epithelial AGS Cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1111/j.1750-3841.2009.01194.xzh_TW
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