Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70098
標題: Ameliorative effects of Vaccaria segetalis extract on osteopenia in ovariectomized rats
作者: Shih, C.C.
Lin, C.H.
Lin, W.L.
關鍵字: Vaccaria segetalis
Ovariectomy
Osteopenia
estrogen-like activity
prevents bone loss
serum-cholesterol
triterpenoid saponins
cyclic-peptides
17-beta-estradiol
hcl
hypertrophy
resorption
tamoxifen
期刊/報告no:: Journal of Natural Medicines, Volume 63, Issue 4, Page(s) 386-392.
摘要: The purpose of this study was to determine the ameliorative effects of a crude extract of Vaccaria segetalis (Neck.) Garcke (Caryophyllaceae) (VSE) on osteopenia in ovariectomized (OVX) rats over 12 weeks. Rats were divided into the sham and OVX groups. The OVX rats were allowed to lose bone for 6 weeks. At 6 weeks post-OVX, the OVX rats were divided into four groups treated with water, 17 beta-estradiol (30 mu g/kg, daily subcutaneous injection), or VSE (0.5 or 1.0 g/kg, daily, orally) for 6 weeks. In OVX rats, the increases of serum total cholesterol were significantly decreased by VSE or 17 beta-estradiol treatment. There were decreases in bone density and calcium content, including the left femur and the fourth lumbar vertebra, when compared with the sham control rats. Treatment with 17 beta-estradiol or VSE ameliorated these changes induced by OVX. In addition, ovariectomy increased urinary deoxypyridinoline (DPD) amounts (P < 0.001). The increases were suppressed by 17 beta-estradiol and 0.5 or 1.0 g/kg VSE (P < 0.01, P < 0.05, P < 0.01, respectively). Our results demonstrated that VSE ameliorates ovariectomy-induced osteopenia by inhibition of bone resorption.
URI: http://hdl.handle.net/11455/70098
ISSN: 1340-3443
文章連結: http://dx.doi.org/10.1007/s11418-009-0341-9
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