Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70151
標題: A comparison of biodistribution between In-111-DTPA octreotide and In-111-DOTATOC in rats bearing pancreatic tumors
作者: Lin, Y.C.
Hung, G.U.
Luo, T.Y.
Chen, C.H.
Hsia, C.C.
Chen, S.L.
Ho, Y.J.
Lin, W.Y.
關鍵字: In-111-DOTATOC
In-111-DTPA octreotide
pancreatic tumor
rat
somatostatin-receptor scintigraphy
neuroendocrine tumors
radionuclide
therapy
radiotherapy
experience
dosimetry
diagnosis
lymphoma
subtypes
analog
期刊/報告no:: Journal of Veterinary Medical Science, Volume 68, Issue 4, Page(s) 367-371.
摘要: In-111-DTPA octreotide (DTPAOC) has been used for detecting somatostatin receptor positive tumor for years. In-111 DOTA-Tyr3-octreotide (DOTATOC) is newly developed for diagnostic and therapeutic purposes. In this study, we compared the biodistribution and tumor uptake ratio after injection of In-111 DTPAOC and In-111 DOTATOC in rats. Twelve rats bearing pancreatic tumors were divided into two groups: six rats were sacrificed at 4 hr after injection of 3.7 MBq of In-111 DTPAOC and another 6 rats were sacrificed at the same time after injection of 3.7 MBq of In-111 DOTATOC. Samples of various organs were obtained and counted to calculate the tissue concentration. In addition, 12 rats bearing pancreatic tumors were scanned at 4, 24, and 48 hr after injection of 37 MBq of In-111 DTPAOC or In-111 DOTATOC. The tumor uptake ratios (T/N ratio) were calculated. The biodistribution data showed that the activity in the tumor as well as in the kidney was significantly higher in the In-111 DOTATOC group than in the In-111 DTPAOC group, although both radiopharmaceuticals had the expected high affinity to the tumor. The T/N ratios in the In-111 DOTATOC group were also significantly higher than those in the In-111 DTPAOC group at 24 hr after injection. We conclude that In-111 DOTATOC showed lower clearance than In-111 DTPAOC in the rats bearing pancreatic tumors, although both of these radiopharmaceuticals showed expected high tumor uptake.
URI: http://hdl.handle.net/11455/70151
ISSN: 0916-7250
文章連結: http://dx.doi.org/10.1292/jvms.68.367
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