Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70222
標題: Chronic consumption of raw but not boiled Welsh onion juice inhibits rat platelet function
作者: Chen, J.H.
Chen, H.
Tsai, S.J.
Jen, C.J.
關鍵字: platelet function
Welsh onion
prostaglandins
bleeding time
rats
arachidonic-acid
aggregation
exercise
endothelium
thromboxane
allium
期刊/報告no:: Journal of Nutrition, Volume 130, Issue 1, Page(s) 34-37.
摘要: Welsh onion has been consumed for prevention of cardiovascular disorders. To study if it has antithrombotic effects, 8-wk-old male Sprague-Dawley rats were studied. Some rats were fed raw or boiled Welsh onion juice (2 g . kg(-1) . d(-1)) for 4 wk, and the remaining acted as the control. Before and after feeding, their systolic blood pressure was measured by a tail-cuff method. Two days after the treatment period, tail bleeding time, platelet function (including platelet aggregation and adhesion), plasma levels of prostaglandins, and platelet cyclic nucleotide levels were determined, In comparison to the control, raw Welsh onion juice consumption significantly (1) lowered resting systolic blood pressure; (2) prolonged the bleeding time; (3) diminished platelet adhesion on a fibrinogen-coated surface, ADP-evoked platelet aggregation and ADP-stimulated thromboxane release; (4) elevated the concentration of cyclic AMP, but not cyclic GMP, in platelets; (5) increased the plasma level of 6-keto-prostaglandin F-1 alpha, the stable prostacyclin metabolite, but not the plasma nitrite level. On the contrary, boiled Welsh onion juice consumption was totally ineffective, In conclusion, consuming raw Welsh onion juice, but not boiled juice, has blood pressure lowering and antithrombotic effects in rats. These effects may be mediated by PGI(2)-cAMP pathway.
URI: http://hdl.handle.net/11455/70222
ISSN: 0022-3166
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