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|標題:||Activation mechanisms for pseudomonas species lipase by cardiovascular drugs in vitro|
|期刊/報告no：:||Journal of the Chinese Chemical Society, Volume 54, Issue 6, Page(s) 1601-1606.|
|摘要:||The goal of this work was to determine the reaction mechanism for Pseudomonas species lipase activation by cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride based on the results from enzyme kinetics. These drugs are the essential activators of Pseudomonas species lipase in the presence of triton-X 100 or taurochloate in vitro. Moreover, QSAR studies show that the pK(A) values are correlated with the molecular weights of these drugs.|
|Appears in Collections:||期刊論文|
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