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標題: One-Pot Alkoxylation of Phenols with Urea and 1,2-Glycols
作者: Lin, H.Y.
Dai, S.A.
關鍵字: Alkoxylation
Green process
期刊/報告no:: Journal of the Chinese Chemical Society, Volume 57, Issue 2, Page(s) 167-173.
摘要: A one-pot epoxide-free alkoxylation process has been developed for phenolic compounds. The process involves heating phenols and urea in 1,2-glycols at 170-190 degrees C using Na(2)CO(3)/ZnO as co-catalysts under atmospheric conditions During the course of this new alkoxylation reaction, a five-membered ring cyclic carbonate intermediate, ethylene carbonate (EC) or propylene carbonate (PPC), was produced in-transit as the key intermediate and was subsequently consumed by phenols to form alkoxylated ether alcohols as final products in excellent yields. For instance, phenol, bisphenol A (BPA), hydroquinone and resorcinol were converted into their respective mono-alkoxylated ether alcohols on each of their phenolic groups in 80-95% isolated yields In propoxylation of phenols, this approach shows great product selectivity favoring production of high secondary alcohols over primary alcohols in isomeric ratios of nearing 95/5. Since ammonia (NH(3)) and carbon dioxide (CO(2)) evolving from the reaction can be re-combined in theory into urea for re-use, the overall net-alkoxylation by this approach can be regarded as a simple condensation reaction of phenols with 1,2-glycols giving off water as its by-product This one-pot process is simple, safe and environmentally friendlier than the conventional alkoxylated processes based on ethylene oxide (EO) or propylene oxide (PO) Moreover, this process is particularly well-suited for making short chain-length alkoxyether alcohols of phenols.
ISSN: 0009-4536
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