請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70554
標題: Magnetically enhanced high-specificity virus detection using magnetic nanoparticles with antibodies as labeling markers
作者: Yang, S.Y.
Wang, W.C.
Lan, C.B.
Chen, C.H.
Chieh, J.J.
Horng, H.E.
Hong, C.Y.
Yang, H.C.
Tsai, C.P.
Yang, C.Y.
Cheng, I.C.
Chung, W.C.
關鍵字: High specificity
Magnetic nanoparticles
Magnetic field
Virus
cells
期刊/報告no:: Journal of Virological Methods, Volume 164, Issue 1-2, Page(s) 14-18.
摘要: This study describes magnetically driven suppression of cross-reactions among molecules. First, the magnetic nanoparticles are coated with bio-probes and dispersed in liquid. The bio-probes can then bind with homologous or heterologous bio-targets. When alternating-current (ac) magnetic fields are applied, magnetic nanoparticles rotate driven by ac magnetic fields. Thus, the bio-targets bound on the surface of magnetic nanoparticles experience a centrifugal force. The centrifugal force can be manipulated by adjusting the angular frequency of the rotating magnetic nanoparticles. The angular frequency is determined by the applied ac magnetic field frequency. Since the binding force for good binding is much higher than that of poor binding, frequency manipulation is needed for the centrifugal force to be higher than the poor-binding force but lower than the good-binding force. Therefore, poor binding which contributes to cross reactions between molecules can be suppressed efficiently by control of the ac magnetic field frequency. (C) 2009 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/11455/70554
ISSN: 0166-0934
文章連結: http://dx.doi.org/10.1016/j.jviromet.2009.11.016
顯示於類別:期刊論文

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