請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70586
標題: Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo
作者: Tsou, M.F.
Peng, C.T.
Shih, M.C.
Yang, J.S.
Lu, C.C.
Chiang, J.H.
Wu, C.L.
Lin, J.P.
Lo, C.
Fan, M.J.
Chung, J.G.
關鍵字: Benzyl isothiocyanate (BITC)
WEHI-3 leukemia cells
BALB/c mice
Immune
response
Cytotoxicity
mitochondrial death pathway
activated protein-kinases
cycle arrest
cancer-risk
carcinoma-cells
crude extracts
breast-cancer
a/j mice
kappa-b
apoptosis
期刊/報告no:: Leukemia Research, Volume 33, Issue 11, Page(s) 1505-1511.
摘要: Many evidences have shown that dietary intake of cruciferous vegetables could protect against the risk of various types of malignancies. Benzyl isothiocyanate (BITC), one of the compounds from cruciferous vegetables, had shown induced cell cycle arrest and apoptosis in cancer cells. However, there is no available information to address that BITC affects murine leukemia cells in vitro and in vivo. Here, we investigated in vitro effects of BITC on murine leukemia WEHI-3 cells. BITC decreased the percentage of viable cells via GO/G1 arrest and apoptosis in WEHI-3 cells. BITC induced apoptosis through the dysfunction of mitochondria (decreased the levels of mitochondria membrane potential) and activation of caspase-3. Then we investigated in vivo effects of BITC on murine leukemia WEHI-3 cells and the results indicated that BITC decreased the weights of liver and spleen and it also decreased the percentage of CD11b and Mac-3 markers, indicating that the differentiation of the precursor of macrophage and B cells was inhibited. BITC promoted the activity of macrophage phagocytosis in cells which are isolated from PBMC and peritoneal (i.p.). Taken together, BITC can affect WEHI-3 cells in vitro and in vivo. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/70586
ISSN: 0145-2126
文章連結: http://dx.doi.org/10.1016/j.ieukres.2009.01.030
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