請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70593
標題: Wood smoke-induced airway hyperreactivity in guinea pigs: Time course, and role of leukotrienes and hydroxyl radical
作者: Hsu, T.H.
Lai, Y.L.
Kou, Y.R.
關鍵字: leukotriene D-4-receptor antagonist
hydroxyl radical scavenger
airway
C-fiber afferents
inhaled irritants
bronchoconstriction
cigarette-smoke
substance-p
induced bronchoconstriction
sensory
neuropeptides
alveolar macrophages
hyperresponsiveness
responses
hyperpnea
release
responsiveness
期刊/報告no:: Life Sciences, Volume 66, Issue 11, Page(s) 971-980.
摘要: A prior airway exposure to wood smoke induces a tachykinin-dependant increase in airway responsiveness to the subsequent smoke inhalation in guinea pigs (Life Sci. 63: 1513, 1998). To further investigate the time course of, and the contribution of other chemical mediators to, this smoke-induced airway hyperresponsiveness (SIAHR), two smoke challenges teach 10 mi) separated by 30 min were delivered into the lungs of anesthetized guinea pigs by a respirator. In the control animals, the SIAHR was evidenced by the bronchoconstrictive response to the second smoke challenge (SM2) which was similar to 5.2-fold greater than that to the first challenge (SM1). This SIAHR was alleviated by shortening the elapsed time between SM1 and SM2 to 10 min or by extending it to 60 min, and was abolished by extending it to 120 min. This SIAHR was reduced by pretreatment with either MK-571 (a leukotriene D-4-receptor antagonist) or dimethylthiourea (a hydroxyl radical scavenger), but was not affected by pretreatment with either pyrilamine (a histamine H-1-receptor antagonist) or indomethacin (a cyclooxygenase inhibitor). The smoke-induced reduction in the neutral endopeptidase activity (a major enzyme for tachykinin degradation) measured in airway tissues excised 30 min post SM1 was largely prevented by pretreatment with dimethylthiourea. However, this reduction was not seen in airway tissues excised 120 min post SM1. These results suggest that 1) the SIAHR to inhaled wood smoke has a rapid onset time following smoke inhalation and lasts for less than two hours, 2) leukotrienes and hydroxyl radical may play contributory roles in the development of this SIAHR, and 3) hydroxyl radical is the major factor responsible for the smoke-induced inactivation of airway neutral endopeptidase, which may possibly participate in the development of this SIAHR.
URI: http://hdl.handle.net/11455/70593
ISSN: 0024-3205
文章連結: http://dx.doi.org/10.1016/s0024-3205(99)00662-1
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