Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70600
標題: Antinucleosome antibodies as a potential biomarker for the evaluation of renal pathological activity in patients with proliferative lupus nephritis
作者: Hung, W.T.
Chen, Y.M.
Lan, J.L.
Chen, H.H.
Chen, Y.H.
Chen, D.Y.
Hsieh, C.W.
Wen, M.C.
關鍵字: activity index
antinucleosome antibody
chronicity
index
lupus
nephritis
renal biopsy
anti-nucleosome antibodies
disease-activity marker
long-term
prognosis
histologic patterns
erythematosus
glomerulonephritis
classification
autoantibodies
chromatin
injury
期刊/報告no:: Lupus, Volume 20, Issue 13, Page(s) 1404-1410.
摘要: The objective of this study is to evaluate the correlation between antinucleosome antibodies and renal pathological activity in patients with proliferative lupus nephritis (LN). We evaluated 36 patients with proliferative LN, 14 non-renal lupus patients and 10 healthy volunteers. Lupus activity was assessed using the British Isles Lupus Assessment Group 2004 (BILAG 2004) index, serum anti-double stranded DNA (anti-dsDNA) levels, serum complement levels and daily urinary protein levels. All 36 lupus nephritis patients received renal biopsy. Antinucleosome antibodies were detected by enzyme-linked immunosorbent assay (ELISA). Our results showed that levels of serum antinucleosome antibodies were significantly higher in LN patients (median 90.35 units/ml, interquartile range [IQR] 37.38-135.23) than in non-renal SLE patients (median 5.45 units/ml, IQR 2.6-28.93, p < 0.05) and in healthy volunteers (median 3.35 units/ml, IQR 2.95-5.23, p < 0.001). Serum levels of antinucleosome antibodies were positively correlated with BILAG index (Spearman's r = 0.645, p < 0.001) and serum anti-dsDNA antibody levels (r(s) = 0.644, p < 0.01), while serum levels of antinucleosome antibodies were negatively correlated with serum levels of C3 (r(s) = -0.400, p < 0.01) and C4 (r(s) = -0.300, p < 0.05). Serum levels of antinucleosome antibodies were positively correlated with the histological activity index of LN (r(s) = 0.368, p < 0.05). However, there was no significant correlation between serum levels of antinucleosome antibodies and the histological chronicity index. In conclusion, the serum level of antinucleosome antibodies is a potential biomarker for early recognition of renal involvement and evaluation of disease activity in SLE. Our preliminary results suggested that serum levels of antinucleosome antibodies might be a potential biomarker in evaluating pathological activity of LN. Lupus (2011) 20, 1404-1410.
URI: http://hdl.handle.net/11455/70600
ISSN: 0961-2033
文章連結: http://dx.doi.org/10.1177/0961203311417033
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