Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70601
標題: Association of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwan
作者: Lu, J.J.Y.
Chen, D.Y.
Hsieh, C.W.
Lan, J.L.
Lin, F.J.
Lin, S.H.
關鍵字: EBV loads
EBV nuclear antigen-1 (EBNA-1)
Epstein-Barr virus (EBV)
real-time quantitative polymerase chain reaction (RQ-PCR)
systemic
lupus erythematosus (SLE)
connective-tissue diseases
altered immune-response
human b-cells
nasopharyngeal carcinoma
rheumatoid-arthritis
peptide immunization
humoral autoimmunity
nuclear antigen-1
antibodies
sera
期刊/報告no:: Lupus, Volume 16, Issue 3, Page(s) 168-175.
摘要: An association between Epstein-Barr virus (EBV) infection and systemic lupus erythematosus (SLE) has been suggested from previous serologic evidence. Since most adults in Taiwan are EBV-infected, seroepiderniologic studies based on standard assays for EBV are unlikely to dissociate SLE patients and control groups. We reexamine this question by using novel methodologies in which IgA anti-EBV-coded nuclear antigens-1 (EBNA-1) and IgG anti-EBV DNase antibodies were analysed by ELISA, and EBV viral loads were detected by real-time quantitative PCR for 93 adult SLE patients and 370 age-, sex- and living place-matched healthy controls in Taiwan. The specificities of antibodies for extractible nuclear antigens were determined by Western blot. Our results show that IgA anti-EBV EBNA I antibodies were detectable in 31.2% SLE patients; but only in 4.1% of controls (odds ratio [OR] = 10.72, 95% confidence interval [Cl] = 5.19-22.35; P < 10(-7)), IgG anti-EBV DNase antibodies were detected in 53.8% SLE patients but only in 12.2% controls (OR = 8.40, 95% CI = 4.87-14.51; P < 10(-7)). EBV DNA was amplifiable from the sera of 41.9% SLE patients but from only 3.24% controls (P < 0.05). A significant association of IgG anti-EBV DNase antibodies with anti-Sm/RNP antibodies was observed (P < 0.005). The higher seroreactivity and higher copy numbers of EBV genome indicated association of EBV infection with SLE in Taiwan.
URI: http://hdl.handle.net/11455/70601
ISSN: 0961-2033
文章連結: http://dx.doi.org/10.1177/0961203306075800
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