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dc.contributor.authorLu, J.J.Y.en_US
dc.contributor.authorChen, D.Y.en_US
dc.contributor.authorHsieh, C.W.en_US
dc.contributor.authorLan, J.L.en_US
dc.contributor.authorLin, F.J.en_US
dc.contributor.authorLin, S.H.en_US
dc.description.abstractAn association between Epstein-Barr virus (EBV) infection and systemic lupus erythematosus (SLE) has been suggested from previous serologic evidence. Since most adults in Taiwan are EBV-infected, seroepiderniologic studies based on standard assays for EBV are unlikely to dissociate SLE patients and control groups. We reexamine this question by using novel methodologies in which IgA anti-EBV-coded nuclear antigens-1 (EBNA-1) and IgG anti-EBV DNase antibodies were analysed by ELISA, and EBV viral loads were detected by real-time quantitative PCR for 93 adult SLE patients and 370 age-, sex- and living place-matched healthy controls in Taiwan. The specificities of antibodies for extractible nuclear antigens were determined by Western blot. Our results show that IgA anti-EBV EBNA I antibodies were detectable in 31.2% SLE patients; but only in 4.1% of controls (odds ratio [OR] = 10.72, 95% confidence interval [Cl] = 5.19-22.35; P < 10(-7)), IgG anti-EBV DNase antibodies were detected in 53.8% SLE patients but only in 12.2% controls (OR = 8.40, 95% CI = 4.87-14.51; P < 10(-7)). EBV DNA was amplifiable from the sera of 41.9% SLE patients but from only 3.24% controls (P < 0.05). A significant association of IgG anti-EBV DNase antibodies with anti-Sm/RNP antibodies was observed (P < 0.005). The higher seroreactivity and higher copy numbers of EBV genome indicated association of EBV infection with SLE in Taiwan.en_US
dc.relation.ispartofseriesLupus, Volume 16, Issue 3, Page(s) 168-175.en_US
dc.subjectEBV loadsen_US
dc.subjectEBV nuclear antigen-1 (EBNA-1)en_US
dc.subjectEpstein-Barr virus (EBV)en_US
dc.subjectreal-time quantitative polymerase chain reaction (RQ-PCR)en_US
dc.subjectlupus erythematosus (SLE)en_US
dc.subjectconnective-tissue diseasesen_US
dc.subjectaltered immune-responseen_US
dc.subjecthuman b-cellsen_US
dc.subjectnasopharyngeal carcinomaen_US
dc.subjectpeptide immunizationen_US
dc.subjecthumoral autoimmunityen_US
dc.subjectnuclear antigen-1en_US
dc.titleAssociation of Epstein-Barr virus infection with systemic lupus erythematosus in Taiwanen_US
dc.typeJournal Articlezh_TW
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