請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70742
標題: Role of Cybr, a cytohesin binder and regulator, in CD4(+) T-cell function and host immunity
作者: Chang, S.L.
Chang, C.L.T.
Huang, P.I.
Tao, M.H.
Yang, W.C.
關鍵字: Cybr
MAP kinase
T-bet
IFN-gamma
T cells
Transgenic mice
nucleotide exchange factors
scaffolding protein casp
interferon-gamma
ifn-gamma
signaling pathway
dendritic cells
bet expression
activation
receptor
lymphocytes
期刊/報告no:: Molecular Immunology, Volume 46, Issue 16, Page(s) 3218-3223.
摘要: Cytohesin binder and regulator (Cybr) is known to regulate leukocyte adhesion and migration. However, its function in T-cells is poorly understood. Here, we investigated the role of Cybr in CD4(+) T-cell function and host immunity. Cybr inhibited p38 phosphorylation following CD4(+) T-cell stimulation. Since p38 regulates the expression of T-box expressed in T-cells (T-bet) but not GATA binding protein 3 (GATA-3) in T-cells, Cybr decreased the expression of T-bet and IFN-gamma in CD4(+) T-cells. Moreover, we found that host immunity against Listeria infection and IFN-gamma production in blood were significantly compromised in Cybr-overexpressing transgenic mice. In summary, our data suggest that Cybr represses the expression of T-bet and IFN-gamma via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice. (C) 2009 Published by Elsevier Ltd.
URI: http://hdl.handle.net/11455/70742
ISSN: 0161-5890
文章連結: http://dx.doi.org/10.1016/j.molimm.2009.08.014
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