請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/70851
標題: Dietary Effect of Antrodia Camphorate Extracts on Immune Responses in WEHI-3 Leukemia BALB/c Mice
作者: Lin, S.Y.
Sheen, L.Y.
Chiang, B.H.
Yang, J.S.
Pan, J.H.
Chang, Y.H.
Hsu, Y.M.
Chiang, J.H.
Lu, C.C.
Wu, C.L.
Chung, J.G.
關鍵字: breast-cancer cells
in-vivo
submerged culture
hepatic toxicity
fruiting bodies
apoptosis
mycelia
induction
rats
polysaccharides
期刊/報告no:: Nutrition and Cancer-an International Journal, Volume 62, Issue 5, Page(s) 593-600.
摘要: Antrodia camphorata has been recognized to be a traditional Chinese medicine for abdominal pain, diarrhea, and to protect against hepatitis virus infection. Several ingredients derived from A. camphorata possess various pharmacological and biological activities such as antioxidant and anticancer. In this study, its ability to promote immune responses and to exhibited antileukemia activity in WEHI-3 leukemia BALB/c mice were investigated. The results indicated A. camphorata significantly prolonged the survival rate and prevented the body weight loss in leukemia mice. Four mg/kg of A. camphorata treatment significantly decreased the weight of the spleen. Both doses (2 and 4 mg/kg) of A. camphorata did not affect Mac-3 marker in leukocytes. However, the 4 mg/kg of A. camphorata decreased the levels of CD11b and both doses of treatment increased CD3 and CD19. With lipopolysaccharide stimulation, the 4 mg/kg of A. camphorata promoted the significant proliferation of leukocytes; but with concanavalin A stimulation, both doses promoted the significant proliferation of leukocytes. YAC-1 target cells were killed by NK cells from the mice after treatment with A. camphorata at 4 mg/kg in target cells at a ratio of 50:1. The percentage of macrophages with phagocyted at A. camphorata treatment increased, and these effects were in dose-dependent manners.
URI: http://hdl.handle.net/11455/70851
ISSN: 0163-5581
文章連結: http://dx.doi.org/10.1080/01635580903532341
顯示於類別:期刊論文

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。