Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/70884
標題: A Flexible Strategy Based on a C-2-Symmetric Pool of Chiral Substrates: Concise Synthesis of (+)-Valienamine, Key Intermediate of (+)- Pancratistatin, and Conduramines A-1 and E
作者: Chang, Y.K.
Lo, H.J.
Yan, T.H.
關鍵字: ring-closing metathesis
baylis-hillman reaction
efficient synthesis
allylic azides
enantiospecific syntheses
microbial oxidation
valienamine
inhibitors
validamycin
conduritols
期刊/報告no:: Organic Letters, Volume 11, Issue 19, Page(s) 4278-4281.
摘要: A new strategy invoking a new application of the [3,3] sigmatropic rearrangement of allylic azides and the presence of a C-2 symmetry element within a pool of chiral substrates was evolved. Not only does this simple flexible strategy provide a concise approach to (+)-valienamine, but it also can readily be adopted for the synthesis of conduramines A-1 and E and the enantiopure azido carbonate 4, a key intermediate of (+)-pancratistatin.
URI: http://hdl.handle.net/11455/70884
ISSN: 1523-7060
文章連結: http://dx.doi.org/10.1021/ol9016194
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